For the reduction of hypersensitivity in exposed cervical areas and on teeth prepared to receive a restoration or a fixed prosthesis.
Doctor / Assistant – Under every restoration
Use GLUMA® Desensitizer below every restoration – direct and indirect – to ensure your patients the comfort they deserve.
Dental hygienist – Desensitization
Patients will appreciate the fast, effective and long-term results of a comfortable prophylaxis.
Schematic representation of effect:
Blue: Intradental sealing induced by GLUMA Desensitizer within dentinal tubuli
SEM of GLUMA-induced septa in dentinal tubuli.¹
SEM magnification of a single Gluma-induced septum in dentinal tube.¹
1 Source: Schweppe J, Hoffmann M, Kastrati A, Utterodt A, Riedel N, Schaub M: Effect of GLUMA Desensitizer on Bond Strength of Etch & Rinse Adhesives. J Dent Res 90 (Spec Issue A): 3172, 2011.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel are indicated for the treatment of hypersensitive dentine. They eliminate pain in exposed cervical areas which do not require restoration, and alleviate or prevent dentinal sensitivity after preparing the teeth to receive direct or indirect restorations.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel are suitable prior to the placement of direct and indirect restorations. Both desensitizers function solely within the dentinal tubuli. Thus, they do not interfere with dental adhesives nor adhesive resin-based luting materials. In combination with adhesives used in total etch or selective enamel etching technique, GLUMA Desensitizer or GLUMA Desensitizer PowerGel should be applied after phosphoric acid etching. In case of self-etch adhesives, GLUMA Desensitizer or GLUMA Desensitizer PowerGel are to be applied prior to the adhesive.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel should be left on the dentine for 30-60s. Afterwards, they need to be rinsed off with plenty of water.
GLUMA Desensitizer PowerGel contains pigments to ease its application. It does not stain the tooth if it dwells on the tooth for a maximum of 60s. Moreover, it needs to be rinsed off with plenty of water.
Various studies have confirmed that GLUMA Desensitizer and GLUMA Desensitizer PowerGel are fully compatible with dental adhesives and luting cements. The bond strength of these materials to the tooth remains on the same level irrespective of whether GLUMA Desensitizer/GLUMA Desensitizer PowerGel is previously applied on the dentine or not. Some other desensitizing products act only at the tooth surface. This may decrease bond strength to adhesives or cements applied afterwards.1 GLUMA Desensitizer and GLUMA Desensitizer PowerGel do not interfere with these adhesive materials because they work within the dentinal tubuli.
1 Aranha AC et al.: Microtensile bond strengths of composite to dentine treated with desensitizer products. J Adhes Dent. 2006, 2:85-90.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel contain glutardialdehyde. This substance is responsible for the effective reduction of dentine hypersensitivity. It is a highly reactive agent able to coagulate proteins. This effect is desired within the dentine tubuli but not on the gingiva and mucosa. We therefore strongly recommend the use of rubber dam. To avoid irritation of oral soft tissues, GLUMA Desensitizer and GLUMA Desensitizer PowerGel must never touch soft tissue and must be rinsed off with plenty of water by the dentist/dental assistant.
After application on the hypersensitive tooth area, GLUMA Desensitizer/GLUMA Desensitizer PowerGel needs to be airdried. This step increases the desensitizing effect. Afterwards, the desensitizer needs to be rinsed off using plenty of water by the dentist/ dental assistant.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel contain glutardialdehyde. This agent is very effective in the coagulation of proteins, providing the desired result within the dentine tubuli. However, it also reacts with oral soft tissue when it comes in contact with gingiva or mucosa. This may cause temporary local irritations or necrosis of the soft tissue. To avoid any contact with oral soft tissue, rubber dam needs to be applied.
Light-curing does not affect GLUMA Desensitizer and GLUMA Desensitizer PowerGel. Both desensitizers do not contain photocuring ingredients.
The flocked syringe nozzle is ideally suited for applying and distributing the gel on the tooth surface. A more precise application can be achieved by applying the gel with a dental probe.
GLUMA Desensitizer is one of the most evaluated desensitizers worldwide: at least 34 clinical patient studies were done on the performance of GLUMA Desensitizer and numerous in-vitro investigations. (You will find a list of these studies at the end of this document.)
Several clinical studies demonstrated a minimisation of the dentine hypersensitivity directly after its application2. Its full effect will occur after some minutes to hours once the reaction of GLUMA Desensitizer and GLUMA Desensitizer PowerGel with the proteins of the dentine liquor is completed. In some cases, a repeated application of GLUMA Desensitizer or GLUMA Desensitizer PowerGel may be necessary.
2 Mehta D, et al.: Efficacy of Dentin Desensitizing Agents: A Randomized Controlled Clinical Trial. J Dent Res 93 (Spec Iss B), 1115, 2014.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel contain glutardialdehyde and HEMA ((2-Hydroxyethyl)methacrylate). HEMA enables glutardialdehyde to penetrate up to 200μm into the dentine tubuli3. Inside the tubuli, glutardialdehyde reacts with the proteins present in the dentine liquor. The proteins precipitate and form protein plugs which close the dentine tubuli. This protein coagulation leads to the polymerisation of HEMA4. Because of these coagulated proteins (protein septa), the permeability of the dentine is significantly reduced5 and movements of dentine liquor inside the tubuli or other stimulating effects are lessened. GLUMA Desensitizer and GLUMA Desensitizer PowerGel function within the dentine tubuli and therefore do not interfere with adhesive treatments. They do not create a layer on the dentine surface. Other studies have shown further benefits from glutardialdehyde. It inhibits enzymes (MMPs) within the dentine that degrade the hybrid layer of adhesives over time6. Apart from this, glutardialdehyde has also demonstrated its potential for cavity disinfection7. Last but not least, it increases the strength of the dentine and may lead to more durable bonding8.
3 Schüpbach P et al.: Closing of dentinal tubules by Gluma desensitizer. Eur J Oral Sci 1997; 105: 414-421.
4 Qin C et. al.: Spectroscopic investigation of the function of aqueous 2-hydroxyethylmethacrylate/glutaraldehyde solution as a dentin desensitizer. Eur J Oral Sci 114, 2006:354-9.
5 Ishihata H et al.: In vitro dentin permeability after application of Gluma® desensitizer as aqueous solution or aqueous fumed silica dispersion. J Appl Oral Sci 19(2), 2011:147-53.
6 Sabatini C et al.: Inhibition of endogenous human dentin MMPs by Gluma. Dental Mat 30, 2014: 752-8.
7 Felton D et al.: Inhibition of bacterial growth under composite restorations following GLUMA pretreatment. JDR, 68 (3), 1989: 491-5.
8 Bedran-Russo AK et al.: Changes in stiffness of demineralized dentin following application of collagen cross-linkers. J of Biomedical Materials Research Part B: Applied Biomaterials, 86 (B), 2008: 330-4.
A recently published clinical study revealed a reduction of dentine hypersensitivity by GLUMA Desensitizer for at least 18 months9. GLUMA Desensitizer was the only tested desensitizing treatment that did not show an increase in pain during the 18 months study observation period.
9 Lopes AO et al.: Evaluation of different treatment protocols for dentine hypersensitivity: an 18-month randomized clinical trial. Lasers Med Sci, 32, 2017:1023-30.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel have demonstrated their long-term effectiveness of up to 18 months in various clinical studies10.
Both GLUMA Desensitizers are fast and non-invasive. They should only be applied by dentists, though, as they are not intended for use by the patients. They do not interfere with other treatments (e. g. following adhesive treatments) compared to other desensitizing treatments (e.g. desensitizers based on oxalates11, 12). GLUMA Desensitizer and GLUMA Desensitizer PowerGel are more effective than desensitizers based on an oxalate or calcium phosphate chemistry13, 14, 15.
10 Lopes AO et al.: Evaluation of different treatment protocols for dentine hypersensitivity: an 18-month randomized clinical trial. Lasers Med Sci, 32, 2017:1023-30.
11 Silva SMA et al.: Effect of Oxalate Desensitizer on the Durability of Resin-Bonded Interfaces. Operative Dentistry 35-6, 2010: 610-617.
12 Acar O et al.: The effect of dentin desensitizers and Nd:YAG laser pre-treatment on microtensile bond strength of self-adhesive resin cement to dentin. J Adv Prosthodont 6, 2014: 88-95.
13 Dondi Dall‘ Orologio et al.: In vitro and in vivo evaluation of the effectiveness of three dentin desensitizing treatment regimens. American Journal of Dentistry 27 (3), 2014: 139-144.
14 Mehta D et al.: Randomized controlled clinical trial on the efficacy of dentin desensitizing agents. Acta Odontologica Scandinavica. 2014; Early Online, 1–6.
15 Vora J et al.: Effects of two topic desensitizing agents and placebo on dentin hypersensitivity. AJD 25,5, 2012:293-8.
The desensitizing ingredients of GLUMA Desensitizer and GLUMA Desensitizer PowerGel are the same. The differences between both desensitizers lie in the consistency and the colour. GLUMA Desensitizer is a clear liquid whereas GLUMA Desensitizer PowerGel is a greenish gel. The gel product might be easier to control because of its colour and consistency.
The long-term efficacy of both products is similar.
GLUMA Desensitizer is available in 5ml bottle and single dose for one application. GLUMA Desensitizer PowerGel is available in 1g syringe.
GLUMA Desensitizer has been launched in 1992. GLUMA Desensitizer PowerGel followed in 2011. We estimate that GLUMA Desensitizer has been applied on teeth about 45 million times and that 34 studies have been carried out on GLUMA Desensitizer. (You will find a list of these studies at the end of this document.)
GLUMA Desensitizer and GLUMA Desensitizer PowerGel both have a pH value of 3-4.